Mutation Causing Autosomal Dominant Nocturnal Frontal Lobe Epilepsy Alters Ca(2+) Permeability, Conductance, and Gating of Human α4β2 Nicotinic Acetylcholine Receptors

A mutation (S247F) in the channel-lining domain (M2) of the α4 nicotinic acetylcholine receptor (AChR) subunit has previously been linked genetically to autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE). To better understand the functional significance of this mutation, we characterized th...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Kuryatov, Alexander, Gerzanich, Volodymyr, Nelson, Mark, Olale, Felix, Lindstrom, Jon
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 1997
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6573611/
https://ncbi.nlm.nih.gov/pubmed/9364050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.17-23-09035.1997
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