Endogenous Serine Protease Inhibitor Modulates Epileptic Activity and Hippocampal Long-Term Potentiation

Protease nexin-1 (PN-1), a member of the serpin superfamily, controls the activity of extracellular serine proteases and is expressed in the brain. Mutant mice overexpressing PN-1 in brain under the control of the Thy-1 promoter (Thy 1/PN-1) or lacking PN-1 (PN-1−/−) were found to develop epileptic...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Lüthi, Andreas, van der Putten, Herman, Botteri, Florence M., Mansuy, Isabelle M., Meins, Marita, Frey, Uwe, Sansig, Gilles, Portet, Chantal, Schmutz, Markus, Schröder, Markus, Nitsch, Cordula, Laurent, Jean-Paul, Monard, Denis
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 1997
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6573330/
https://ncbi.nlm.nih.gov/pubmed/9169529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.17-12-04688.1997
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