Neuronal Localization of Presenilin-1 and Association with Amyloid Plaques and Neurofibrillary Tangles in Alzheimer’s Disease

Mutations in the presenilin-1 (PS1) gene is a cause of early- onset familial Alzheimer’s disease (AD). Endogenous PS1 is associated with the endoplasmic reticulum in the cell body of undifferentiated SH-SY5Y neuroblastoma cells. At early stages of neuronal differentiation in rat hippocampal culture,...

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Pubblicato in:J Neurosci
Autori principali: Busciglio, Jorge, Hartmann, Henrike, Lorenzo, Alfredo, Wong, Caine, Baumann, Karlheinz, Sommer, Bernd, Staufenbiel, Matthias, Yankner, Bruce A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 1997
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6573321/
https://ncbi.nlm.nih.gov/pubmed/9185547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.17-13-05101.1997
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