Mechanisms of Reduced Striatal NMDA Excitotoxicity in Type I Nitric Oxide Synthase Knock-Out Mice

We investigated the role of neuronal (type I) nitric oxide synthase (nNOS) in NMDA-mediated excitotoxicity in wild-type (SV129 and C57BL/6J) and type I NOS knock-out (nNOS(−/−)) mice and examined its relationship to apoptosis. Excitotoxic lesions were produced by intrastriatal stereotactic NMDA micr...

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Gepubliceerd in:J Neurosci
Hoofdauteurs: Ayata, Cenk, Ayata, Gamze, Hara, Hideaki, Matthews, Russel T., Beal, M. Flint, Ferrante, Robert J., Endres, Matthias, Kim, Albert, Christie, Richard H., Waeber, Christian, Huang, Paul L., Hyman, Bradley T., Moskowitz, Michael A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Society for Neuroscience 1997
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6573288/
https://ncbi.nlm.nih.gov/pubmed/9278526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.17-18-06908.1997
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