Neurotoxicity of the 22 kDa Thrombin-Cleavage Fragment of Apolipoprotein E and Related Synthetic Peptides Is Receptor-Mediated

Potent neurotoxicity is associated with both apolipoprotein E (apoE)-related synthetic peptides and the 22 kDa N-terminal thrombin-cleavage fragment of apoE. Furthermore, the E4 isoform of the 22 kDa fragment is significantly more toxic than the same fragment derived from the E3 isoform, suggesting...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Tolar, Martin, Marques, Marcos A., Harmony, Judith A. K., Crutcher, Keith A.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 1997
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6573216/
https://ncbi.nlm.nih.gov/pubmed/9221767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.17-15-05678.1997
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