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Mechanistic basis of L-lactate transport in the SLC16 solute carrier family

In human and other mammalian cells, transport of L-lactate across plasma membranes is mainly catalyzed by monocarboxylate transporters (MCTs) of the SLC16 solute carrier family. MCTs play an important role in cancer metabolism and are promising targets for tumor treatment. Here, we report the crysta...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Bosshart, Patrick D., Kalbermatter, David, Bonetti, Sara, Fotiadis, Dimitrios
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6573034/
https://ncbi.nlm.nih.gov/pubmed/31201333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10566-6
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