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Structure and function of a monocarboxylate transporter homolog specific for L-lactate

Monocarboxylate transporters play important roles in certain cancers. We have reported structures of an L-lactate-transporting solute carrier family 16 homolog with bound substrate and inhibitor. The structures show the transporter in the pharmacologically relevant outward-open conformation. Structu...

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Podrobná bibliografie
Vydáno v:Mol Cell Oncol
Hlavní autoři: Bosshart, Patrick D., Kalbermatter, David, Bonetti, Sara, Fotiadis, Dimitrios
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6816346/
https://ncbi.nlm.nih.gov/pubmed/31692891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2019.1646605
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