Penetration Efficiency of Antitumor Agents in Ovarian Cancer Spheroids: The Case of Recombinant Targeted Toxin DARPin-LoPE and the Chemotherapy Drug, Doxorubicin

The efficiency of delivering a therapeutic agent into a tumor is among the crucial factors determining the prospects for its clinical use. This problem is particularly acute in the case of targeted antitumor agents since many of them are high-molecular-weight compounds. In this work, the penetration...

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Bibliographic Details
Published in:Pharmaceutics
Main Authors: Sokolova, Evgeniya, Kutova, Olga, Grishina, Alena, Pospelov, Anton, Guryev, Evgeniy, Schulga, Alexey, Deyev, Sergey, Balalaeva, Irina
Format: Artigo
Language:Inglês
Published: MDPI 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6572593/
https://ncbi.nlm.nih.gov/pubmed/31067739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics11050219
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