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Penetration Efficiency of Antitumor Agents in Ovarian Cancer Spheroids: The Case of Recombinant Targeted Toxin DARPin-LoPE and the Chemotherapy Drug, Doxorubicin

The efficiency of delivering a therapeutic agent into a tumor is among the crucial factors determining the prospects for its clinical use. This problem is particularly acute in the case of targeted antitumor agents since many of them are high-molecular-weight compounds. In this work, the penetration...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Pharmaceutics
Hauptverfasser: Sokolova, Evgeniya, Kutova, Olga, Grishina, Alena, Pospelov, Anton, Guryev, Evgeniy, Schulga, Alexey, Deyev, Sergey, Balalaeva, Irina
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6572593/
https://ncbi.nlm.nih.gov/pubmed/31067739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics11050219
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