η-Secretase processing of APP inhibits neuronal activity in the hippocampus

Alzheimer's disease (AD) is characterized by the accumulation of amyloid plaques, which are predominantly composed of amyloid β-peptide (Aβ)1. Two principal physiological pathways either prevent or promote Aβ generation from its precursor (amyloid precursor protein; APP) in a competitive manner...

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Published in:Nature
Main Authors: Willem, Michael, Tahirovic, Sabina, Busche, Marc Aurel, Ovsepian, Saak V., Chafai, Magda, Kootar, Scherazad, Hornburg, Daniel, Evans, Lewis D.B., Moore, Steven, Daria, Anna, Hampel, Heike, Müller, Veronika, Giudici, Camilla, Nuscher, Brigitte, Wenninger-Weinzierl, Andrea, Kremmer, Elisabeth, Heneka, Michael T., Thal, Dietmar R., Giedraitis, Vilmantas, Lannfelt, Lars, Müller, Ulrike, Livesey, Frederick J., Meissner, Felix, Herms, Jochen, Konnerth, Arthur, Marie, Hélène, Haass, Christian
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6570618/
https://ncbi.nlm.nih.gov/pubmed/26322584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14864
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