Visualizing engrafted human cancer and therapy responses in immunodeficient zebrafish

Xenograft cell transplantation into immunodeficient mice has become the gold-standard for assessing pre-clinical efficacy of cancer drugs, yet direct visualization of single cell phenotypes is difficult. Here, we report an optically-clear, prkdc−/−, il2rga−/− zebrafish that lack adaptive and natural...

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Publicat a:Cell
Autors principals: Yan, Chuan, Brunson, Dalton C., Tang, Qin, Do, Daniel, Iftimia, Nicolae A., Moore, John C., Hayes, Madeline N., Welker, Alessandra M., Garcia, Elaine G., Dubash, Taronish D., Hong, Xin, Drapkin, Benjamin J., Myers, David T., Phat, Sarah, Volorio, Angela, Marvin, Dieuwke L., Ligorio, Matteo, Dershowitz, Lyle, McCarthy, Karin M., Karabacak, Murat N., Fletcher, Jonathan A., Sgroi, Dennis, Iafrate, John A., Maheswaran, Shyamala, Dyson, Nick J., Haber, Daniel A., Rawls, John F., Langenau, David M.
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6570580/
https://ncbi.nlm.nih.gov/pubmed/31031007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.04.004
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