Visualizing engrafted human cancer and therapy responses in immunodeficient zebrafish

Xenograft cell transplantation into immunodeficient mice has become the gold-standard for assessing pre-clinical efficacy of cancer drugs, yet direct visualization of single cell phenotypes is difficult. Here, we report an optically-clear, prkdc−/−, il2rga−/− zebrafish that lack adaptive and natural...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Yan, Chuan, Brunson, Dalton C., Tang, Qin, Do, Daniel, Iftimia, Nicolae A., Moore, John C., Hayes, Madeline N., Welker, Alessandra M., Garcia, Elaine G., Dubash, Taronish D., Hong, Xin, Drapkin, Benjamin J., Myers, David T., Phat, Sarah, Volorio, Angela, Marvin, Dieuwke L., Ligorio, Matteo, Dershowitz, Lyle, McCarthy, Karin M., Karabacak, Murat N., Fletcher, Jonathan A., Sgroi, Dennis, Iafrate, John A., Maheswaran, Shyamala, Dyson, Nick J., Haber, Daniel A., Rawls, John F., Langenau, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6570580/
https://ncbi.nlm.nih.gov/pubmed/31031007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.04.004
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