Visualizing engrafted human cancer and therapy responses in immunodeficient zebrafish

Xenograft cell transplantation into immunodeficient mice has become the gold-standard for assessing pre-clinical efficacy of cancer drugs, yet direct visualization of single cell phenotypes is difficult. Here, we report an optically-clear, prkdc−/−, il2rga−/− zebrafish that lack adaptive and natural...

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Pubblicato in:Cell
Autori principali: Yan, Chuan, Brunson, Dalton C., Tang, Qin, Do, Daniel, Iftimia, Nicolae A., Moore, John C., Hayes, Madeline N., Welker, Alessandra M., Garcia, Elaine G., Dubash, Taronish D., Hong, Xin, Drapkin, Benjamin J., Myers, David T., Phat, Sarah, Volorio, Angela, Marvin, Dieuwke L., Ligorio, Matteo, Dershowitz, Lyle, McCarthy, Karin M., Karabacak, Murat N., Fletcher, Jonathan A., Sgroi, Dennis, Iafrate, John A., Maheswaran, Shyamala, Dyson, Nick J., Haber, Daniel A., Rawls, John F., Langenau, David M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6570580/
https://ncbi.nlm.nih.gov/pubmed/31031007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.04.004
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