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PLK4 promotes centriole duplication by phosphorylating STIL to link the procentriole cartwheel to the microtubule wall

Centrioles play critical roles in organizing the assembly of the mitotic spindle and templating the formation of primary cilia. Centriole duplication occurs once per cell cycle and is regulated by Polo-like kinase 4 (PLK4). Although significant progress has been made in understanding centriole compo...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Moyer, Tyler Chistopher, Holland, Andrew Jon
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6570480/
https://ncbi.nlm.nih.gov/pubmed/31115335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.46054
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