Increased Neuronal Endocytosis and Protease Delivery to Early Endosomes in Sporadic Alzheimer’s Disease: Neuropathologic Evidence for a Mechanism of Increased β-Amyloidogenesis

The early endosome is the first vacuolar compartment along the endocytic pathway. It is the site of internalization and initial processing of amyloid precursor protein (APP) and apolipoprotein E (ApoE), two proteins of etiological importance in Alzheimer’s disease, and a putative site of β-amyloid p...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Cataldo, Anne M., Barnett, Jody L., Pieroni, Cristiana, Nixon, Ralph A.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 1997
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6568334/
https://ncbi.nlm.nih.gov/pubmed/9236226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.17-16-06142.1997
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