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Molecular and Cellular Characterization of SIRT1 Allosteric Activators
SIRT1 is an NAD(+)-dependent lysine deacetylase that promotes healthy aging and longevity in diverse organisms. Small molecule allosteric activators of SIRT1 such as resveratrol and SRT2104 directly bind to the N-terminus of SIRT1 and lower the K(m) for the protein substrate. In rodents, sirtuin-act...
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| Publié dans: | Methods Mol Biol |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6567996/ https://ncbi.nlm.nih.gov/pubmed/31087296 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-4939-9434-2_8 |
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