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Deacylcynaropicrin Inhibits RANKL-Induced Osteoclastogenesis by Inhibiting NF-κB and MAPK and Promoting M2 Polarization of Macrophages

Inflammation can promote the maturity of osteoclasts and bone resorption in many bone disease such as osteoporosis and arthritis. Here, we aimed to investigate the inhibitory effects of deacylcynaropicrin (DAC) on osteoclastogenesis and bone resorption induced by RANKL. Bone-marrow-derived macrophag...

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Bibliografske podrobnosti
izdano v:Front Pharmacol
Main Authors: Li, Zhikun, Zhu, Xiaodong, Xu, Ruijun, Wang, Yi, Hu, Ruixi, Xu, Wei
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6567936/
https://ncbi.nlm.nih.gov/pubmed/31231214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00599
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