Inhibition of mPGES-1 or COX-2 Results in Different Proteomic and Lipidomic Profiles in A549 Lung Cancer Cells

Pharmacological inhibition of microsomal prostaglandin E synthase (mPGES)-1 for selective reduction in prostaglandin E(2) (PGE(2)) biosynthesis is protective in experimental models of cancer and inflammation. Targeting mPGES-1 is envisioned as a safer alternative to traditional non-steroidal anti-in...

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Udgivet i:Front Pharmacol
Main Authors: Bergqvist, Filip, Ossipova, Elena, Idborg, Helena, Raouf, Joan, Checa, Antonio, Englund, Karin, Englund, Petter, Khoonsari, Payam Emami, Kultima, Kim, Wheelock, Craig E., Larsson, Karin, Korotkova, Marina, Jakobsson, Per-Johan
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6567928/
https://ncbi.nlm.nih.gov/pubmed/31231223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00636
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