Changes in the gut microbiome and fermentation products concurrent with enhanced longevity in acarbose-treated mice

BACKGROUND: Treatment with the α-glucosidase inhibitor acarbose increases median lifespan by approximately 20% in male mice and 5% in females. This longevity extension differs from dietary restriction based on a number of features, including the relatively small effects on weight and the sex-specifi...

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Udgivet i:BMC Microbiol
Main Authors: Smith, Byron J, Miller, Richard A, Ericsson, Aaron C, Harrison, David C, Strong, Randy, Schmidt, Thomas M
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6567620/
https://ncbi.nlm.nih.gov/pubmed/31195972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12866-019-1494-7
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