Antitumor activity of dual blockade of PD-L1 and MEK in NSCLC patients derived three-dimensional spheroid cultures

BACKGROUND: Anti-PD-1/PD-L1 drugs are effective as monotherapy in a proportion of NSCLC patients and there is a strong rationale for combining them with targeted therapy. Inhibition of MAPK pathway may have pleiotropic effects on the microenvironment. This work investigates the efficacy of combining...

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Bibliografiske detaljer
Udgivet i:J Exp Clin Cancer Res
Main Authors: Della Corte, Carminia Maria, Barra, Giusi, Ciaramella, Vincenza, Di Liello, Raimondo, Vicidomini, Giovanni, Zappavigna, Silvia, Luce, Amalia, Abate, Marianna, Fiorelli, Alfonso, Caraglia, Michele, Santini, Mario, Martinelli, Erika, Troiani, Teresa, Ciardiello, Fortunato, Morgillo, Floriana
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6567578/
https://ncbi.nlm.nih.gov/pubmed/31196138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1257-1
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