Activity and molecular targets of pioglitazone via blockade of proliferation, invasiveness and bioenergetics in human NSCLC

BACKGROUND: Pioglitazone, a synthetic peroxisome proliferator activated receptor (PPAR-γ) ligand, is known as an antidiabetic drug included in the thiazolidinediones (TZDs) class. It regulates the lipid and glucose cell metabolism and recently a role in the inhibition of numerous cancer cell process...

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Bibliographic Details
Published in:J Exp Clin Cancer Res
Main Authors: Ciaramella, Vincenza, Sasso, Ferdinando Carlo, Di Liello, Raimondo, Corte, Carminia Maria Della, Barra, Giusi, Viscardi, Giuseppe, Esposito, Giovanna, Sparano, Francesca, Troiani, Teresa, Martinelli, Erika, Orditura, Michele, De Vita, Ferdinando, Ciardiello, Fortunato, Morgillo, Floriana
Format: Artigo
Language:Inglês
Published: BioMed Central 2019
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6485164/
https://ncbi.nlm.nih.gov/pubmed/31027492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1176-1
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