Metabolic stress in cancer cells induces immune escape through a PI3K-dependent blockade of IFNγ receptor signaling

BACKGROUND: T-cell mediated immunotherapy brought clinical success for many cancer patients. Nonetheless, downregulation of MHC class I antigen presentation, frequently occurring in solid cancers, limits the efficacy of these therapies. Unraveling the mechanisms underlying this type of immune escape...

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Vydáno v:J Immunother Cancer
Hlavní autoři: Marijt, Koen A., Sluijter, Marjolein, Blijleven, Laura, Tolmeijer, Sofie H., Scheeren, Ferenc A., van der Burg, Sjoerd H., van Hall, Thorbald
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6567539/
https://ncbi.nlm.nih.gov/pubmed/31196219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-019-0627-8
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