T cells specific for a TAP-independent self-peptide remain naïve in tumor-bearing mice and are fully exploitable for therapy

Cancers frequently evade immune-recognition by lowering peptide:MHC-I complexes on their cell surface. Limited peptide supply due to TAP-deficiency results in such MHC-I(low) immune-escape variants. Previously, we reported on a category of TAP-independent self-peptides, called TEIPP, with selective...

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Detalles Bibliográficos
Publicado en:Oncoimmunology
Main Authors: Doorduijn, Elien M., Sluijter, Marjolein, Marijt, Koen A., Querido, Bianca J., van der Burg, Sjoerd H., van Hall, Thorbald
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2017
Assuntos:
Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5790395/
https://ncbi.nlm.nih.gov/pubmed/29399388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1382793
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