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The PinX1/NPM interaction associates with hTERT in early-S phase and facilitates telomerase activation

BACKGROUND: Telomere maintenance is an important factor in tumorigenesis. PinX1 is a potent telomerase regulator which also involves in telomerase loading to telomeres. Nucleophosmin (NPM) can partially attenuate PinX1 inhibition of telomerase activity and NPM loading to hTERT requires PinX1. Howeve...

詳細記述

保存先:
書誌詳細
出版年:Cell Biosci
主要な著者: Ho, Sai-Tim, Jin, Rui, Cheung, Derek Hang-Cheong, Huang, Jun-Jian, Shaw, Pang-Chui
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6567508/
https://ncbi.nlm.nih.gov/pubmed/31210926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13578-019-0306-y
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