The PinX1/NPM interaction associates with hTERT in early-S phase and facilitates telomerase activation

BACKGROUND: Telomere maintenance is an important factor in tumorigenesis. PinX1 is a potent telomerase regulator which also involves in telomerase loading to telomeres. Nucleophosmin (NPM) can partially attenuate PinX1 inhibition of telomerase activity and NPM loading to hTERT requires PinX1. Howeve...

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Udgivet i:Cell Biosci
Main Authors: Ho, Sai-Tim, Jin, Rui, Cheung, Derek Hang-Cheong, Huang, Jun-Jian, Shaw, Pang-Chui
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6567508/
https://ncbi.nlm.nih.gov/pubmed/31210926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13578-019-0306-y
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