Deferasirox drives ROS-mediated differentiation and induces interferon-stimulated gene expression in human healthy haematopoietic stem/progenitor cells and in leukemia cells

BACKGROUND: Administration of the iron chelator deferasirox (DFX) in transfusion-dependent patients occasionally results in haematopoiesis recovery by a mechanism remaining elusive. This study aimed to investigate at a molecular level a general mechanism underlying DFX beneficial effects on haematop...

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Vydáno v:Stem Cell Res Ther
Hlavní autoři: Tataranni, Tiziana, Mazzoccoli, Carmela, Agriesti, Francesca, De Luca, Luciana, Laurenzana, Ilaria, Simeon, Vittorio, Ruggieri, Vitalba, Pacelli, Consiglia, Della Sala, Gerardo, Musto, Pellegrino, Capitanio, Nazzareno, Piccoli, Claudia
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6567456/
https://ncbi.nlm.nih.gov/pubmed/31196186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-019-1293-y
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