N-acetylaspartate (NAA) induces neuronal differentiation of SH-SY5Y neuroblastoma cell line and sensitizes it to chemotherapeutic agents

Neuroblastoma is the most commonly extra-cranial solid tumor of childhood frequently diagnosed. The nervous system-specific metabolite N-acetylaspartate (NAA) is synthesized from aspartate and acetyl-CoA in neurons, it is among the most abundant metabolites present in the central nervous system (CNS...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Mazzoccoli, Carmela, Ruggieri, Vitalba, Tataranni, Tiziana, Agriesti, Francesca, Laurenzana, Ilaria, Fratello, Angelo, Capitanio, Nazzareno, Piccoli, Claudia
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5041977/
https://ncbi.nlm.nih.gov/pubmed/27036033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8454
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