Dichloroacetate Affects Mitochondrial Function and Stemness-Associated Properties in Pancreatic Cancer Cell Lines

Targeting metabolism represents a possible successful approach to treat cancer. Dichloroacetate (DCA) is a drug known to divert metabolism from anaerobic glycolysis to mitochondrial oxidative phosphorylation by stimulation of PDH. In this study, we investigated the response of two pancreatic cancer...

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Udgivet i:Cells
Main Authors: Tataranni, Tiziana, Agriesti, Francesca, Pacelli, Consiglia, Ruggieri, Vitalba, Laurenzana, Ilaria, Mazzoccoli, Carmela, Della Sala, Gerardo, Panebianco, Concetta, Pazienza, Valerio, Capitanio, Nazzareno, Piccoli, Claudia
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6562462/
https://ncbi.nlm.nih.gov/pubmed/31109089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8050478
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