Inhibition of N822K T>A mutation-induced constitutive c-KIT activation in AML cells triggers apoptotic and autophagic pathways leading to death

Background: The D816V mutation of c-KIT can constitutively activate tyrosine kinase, thereby promote core binding factor acute myeloid leukemia (CBF-AML) cell proliferation and inhibit apoptosis. Previous studies have indicated similar proliferation and apoptosis between N822K and D816V mutations.Th...

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Detalhes bibliográficos
Publicado no:Int J Med Sci
Main Authors: Xu, Jianping, Zheng, Jinyuan, Fu, Xiaomeng, Wu, Wei, Tao, Linfen, Li, Dan, Lin, Donghong
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6566732/
https://ncbi.nlm.nih.gov/pubmed/31217744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijms.33532
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