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Reductively-labile sulfonate ester protecting groups that are rapidly cleaved by physiological glutathione

Sulfonates are frequently used to endow water solubility on hydrophobic molecules, but the repertoire of sulfonate protecting groups remains limited. Here we describe the first sulfonate esters that can be unmasked by the mild reducing conditions found in live mammalian cells. Self-immolative cleava...

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Bibliografiska uppgifter
I publikationen:Org Biomol Chem
Huvudupphovsmän: Choi, Adam, Miller, Stephen C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6563934/
https://ncbi.nlm.nih.gov/pubmed/28116407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7ob00063d
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