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Reductively-labile sulfonate ester protecting groups that are rapidly cleaved by physiological glutathione

Sulfonates are frequently used to endow water solubility on hydrophobic molecules, but the repertoire of sulfonate protecting groups remains limited. Here we describe the first sulfonate esters that can be unmasked by the mild reducing conditions found in live mammalian cells. Self-immolative cleava...

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Библиографические подробности
Опубликовано в: :Org Biomol Chem
Главные авторы: Choi, Adam, Miller, Stephen C.
Формат: Artigo
Язык:Inglês
Опубликовано: 2017
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6563934/
https://ncbi.nlm.nih.gov/pubmed/28116407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7ob00063d
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