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Reductively-labile sulfonate ester protecting groups that are rapidly cleaved by physiological glutathione

Sulfonates are frequently used to endow water solubility on hydrophobic molecules, but the repertoire of sulfonate protecting groups remains limited. Here we describe the first sulfonate esters that can be unmasked by the mild reducing conditions found in live mammalian cells. Self-immolative cleava...

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書目詳細資料
發表在:Org Biomol Chem
Main Authors: Choi, Adam, Miller, Stephen C.
格式: Artigo
語言:Inglês
出版: 2017
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6563934/
https://ncbi.nlm.nih.gov/pubmed/28116407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7ob00063d
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