A novel dual PPAR-γ agonist/sEH inhibitor treats diabetic complications in a rat model of type 2 diabetes

AIMS/HYPOTHESIS: The metabolic syndrome is a cluster of risk correlates that can progress to type 2 diabetes. The present study aims to evaluate a novel molecule with a dual action against the metabolic syndrome and type 2 diabetes. METHODS: We developed and tested a novel dual modulator, RB394, whi...

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Vydáno v:Diabetologia
Hlavní autoři: Khan, Md Abdul Hye, Kolb, Lauren, Skibba, Melissa, Hartmann, Markus, Blöcher, René, Proschak, Ewgenij, Imig, John D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6563928/
https://ncbi.nlm.nih.gov/pubmed/30032428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-018-4685-0
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