Mammalian Target of Rapamycin (mTOR) and the Proteasome Attenuates IL-1β Expression in Primary Mouse Cardiac Fibroblasts

Background: IL-1β is a highly potent pro-inflammatory cytokine and its secretion is tightly regulated. Inactive pro-IL-1β is transcribed in response to innate immune receptors activating NFκB. If tissue damage occurs, danger signals released from necrotic cells, such as ATP, can activate NLRP3-infla...

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Udgivet i:Front Immunol
Main Authors: Torp, May-Kristin, Yang, Kuan, Ranheim, Trine, Husø Lauritzen, Knut, Alfsnes, Katrine, Vinge, Leif E., Aukrust, Pål, Stensløkken, Kåre-Olav, Yndestad, Arne, Sandanger, Øystein
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6563870/
https://ncbi.nlm.nih.gov/pubmed/31244838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01285
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