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Current clinical use of polygenic scores will risk exacerbating health disparities

Polygenic risk scores (PRS) are poised to improve biomedical outcomes via precision medicine. However, the major ethical and scientific challenge surrounding clinical implementation is that they are many-fold more accurate in European ancestry individuals than others. This disparity is an inescapabl...

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Foilsithe in:Nat Genet
Main Authors: Martin, Alicia R., Kanai, Masahiro, Kamatani, Yoichiro, Okada, Yukinori, Neale, Benjamin M., Daly, Mark J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2019
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6563838/
https://ncbi.nlm.nih.gov/pubmed/30926966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-019-0379-x
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