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Current clinical use of polygenic scores will risk exacerbating health disparities

Polygenic risk scores (PRS) are poised to improve biomedical outcomes via precision medicine. However, the major ethical and scientific challenge surrounding clinical implementation is that they are many-fold more accurate in European ancestry individuals than others. This disparity is an inescapabl...

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Bibliografiske detaljer
Udgivet i:Nat Genet
Main Authors: Martin, Alicia R., Kanai, Masahiro, Kamatani, Yoichiro, Okada, Yukinori, Neale, Benjamin M., Daly, Mark J.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6563838/
https://ncbi.nlm.nih.gov/pubmed/30926966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-019-0379-x
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