Functional genetic variants revealed by massively parallel precise genome editing

A major challenge in genetics is to identify genetic variants driving natural phenotypic variation. However, current methods of genetic mapping have limited resolution. To address this gap, we developed a CRISPR-Cas9-based high-throughput genome editing approach that can introduce thousands of speci...

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Udgivet i:Cell
Main Authors: Sharon, Eilon, Chen, Shi-An A., Khosla, Neil M., Smith, Justin D., Pritchard, Jonathan K., Fraser, Hunter B.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6563827/
https://ncbi.nlm.nih.gov/pubmed/30245013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.08.057
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