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Massively parallel synthetic promoter assays reveal the in vivo effects of binding site variants

Gene promoters typically contain multiple transcription factor binding sites (TFBSs), which may vary in affinity for their cognate transcription factors (TFs). One major challenge in studying cis-regulation is to understand how TFBS variants affect gene expression. We studied the in vivo effects of...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Mogno, Ilaria, Kwasnieski, Jamie C., Cohen, Barak A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cold Spring Harbor Laboratory Press 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3814890/
https://ncbi.nlm.nih.gov/pubmed/23921661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.157891.113
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