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Complex effects of nucleotide variants in a mammalian cis-regulatory element

Cis-regulatory elements (CREs) control gene expression by recruiting transcription factors (TFs) and other DNA binding proteins. We aim to understand how individual nucleotides contribute to the function of CREs. Here we introduce CRE analysis by sequencing (CRE-seq), a high-throughput method for pr...

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Библиографические подробности
Главные авторы: Kwasnieski, Jamie C., Mogno, Ilaria, Myers, Connie A., Corbo, Joseph C., Cohen, Barak A.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2012
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3511131/
https://ncbi.nlm.nih.gov/pubmed/23129659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1210678109
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