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A massively parallel reporter assay reveals context-dependent activity of homeodomain binding sites in vivo

Cone-rod homeobox (CRX) is a paired-like homeodomain transcription factor (TF) and a master regulator of photoreceptor development in vertebrates. The in vitro DNA binding preferences of CRX have been described in detail, but the degree to which in vitro binding affinity is correlated with in vivo e...

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Bibliografiske detaljer
Udgivet i:Genome Res
Main Authors: Hughes, Andrew E.O., Myers, Connie A., Corbo, Joseph C.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6169884/
https://ncbi.nlm.nih.gov/pubmed/30158147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.231886.117
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