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A massively parallel reporter assay reveals context-dependent activity of homeodomain binding sites in vivo

Cone-rod homeobox (CRX) is a paired-like homeodomain transcription factor (TF) and a master regulator of photoreceptor development in vertebrates. The in vitro DNA binding preferences of CRX have been described in detail, but the degree to which in vitro binding affinity is correlated with in vivo e...

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Bibliographic Details
Published in:Genome Res
Main Authors: Hughes, Andrew E.O., Myers, Connie A., Corbo, Joseph C.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2018
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6169884/
https://ncbi.nlm.nih.gov/pubmed/30158147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.231886.117
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