The structural basis for release-factor activation during translation termination revealed by time-resolved cryogenic electron microscopy

When the ribosome encounters a stop codon, it recruits a release factor (RF) to hydrolyze the ester bond between the peptide chain and tRNA. RFs have structural motifs that recognize stop codons in the decoding center and a GGQ motif for induction of hydrolysis in the peptidyl transfer center 70 Å a...

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Vydáno v:Nat Commun
Hlavní autoři: Fu, Ziao, Indrisiunaite, Gabriele, Kaledhonkar, Sandip, Shah, Binita, Sun, Ming, Chen, Bo, Grassucci, Robert A., Ehrenberg, Måns, Frank, Joachim
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6561943/
https://ncbi.nlm.nih.gov/pubmed/31189921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10608-z
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