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The structural basis for release-factor activation during translation termination revealed by time-resolved cryogenic electron microscopy
When the ribosome encounters a stop codon, it recruits a release factor (RF) to hydrolyze the ester bond between the peptide chain and tRNA. RFs have structural motifs that recognize stop codons in the decoding center and a GGQ motif for induction of hydrolysis in the peptidyl transfer center 70 Å a...
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| Publié dans: | Nat Commun |
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| Auteurs principaux: | , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group UK
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6561943/ https://ncbi.nlm.nih.gov/pubmed/31189921 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10608-z |
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