Polymer-tetrodotoxin conjugates to induce prolonged duration local anesthesia with minimal toxicity

There is clinical and scientific interest in developing local anesthetics with prolonged durations of effect from single injections. The need for such is highlighted by the current opioid epidemic. Site 1 sodium channel blockers such as tetrodotoxin (TTX) are extremely potent, and can provide very l...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Zhao, Chao, Liu, Andong, Santamaria, Claudia M., Shomorony, Andre, Ji, Tianjiao, Wei, Tuo, Gordon, Akiva, Elofsson, Hannes, Mehta, Manisha, Yang, Rong, Kohane, Daniel S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6561913/
https://ncbi.nlm.nih.gov/pubmed/31189915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10296-9
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