Polymer-tetrodotoxin conjugates to induce prolonged duration local anesthesia with minimal toxicity

There is clinical and scientific interest in developing local anesthetics with prolonged durations of effect from single injections. The need for such is highlighted by the current opioid epidemic. Site 1 sodium channel blockers such as tetrodotoxin (TTX) are extremely potent, and can provide very l...

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Publicat a:Nat Commun
Autors principals: Zhao, Chao, Liu, Andong, Santamaria, Claudia M., Shomorony, Andre, Ji, Tianjiao, Wei, Tuo, Gordon, Akiva, Elofsson, Hannes, Mehta, Manisha, Yang, Rong, Kohane, Daniel S.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6561913/
https://ncbi.nlm.nih.gov/pubmed/31189915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10296-9
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