Polymer-tetrodotoxin conjugates to induce prolonged duration local anesthesia with minimal toxicity

There is clinical and scientific interest in developing local anesthetics with prolonged durations of effect from single injections. The need for such is highlighted by the current opioid epidemic. Site 1 sodium channel blockers such as tetrodotoxin (TTX) are extremely potent, and can provide very l...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nat Commun
Egile Nagusiak: Zhao, Chao, Liu, Andong, Santamaria, Claudia M., Shomorony, Andre, Ji, Tianjiao, Wei, Tuo, Gordon, Akiva, Elofsson, Hannes, Mehta, Manisha, Yang, Rong, Kohane, Daniel S.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6561913/
https://ncbi.nlm.nih.gov/pubmed/31189915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10296-9
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