Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression

The Polycomb system modifies chromatin and plays an essential role in repressing gene expression to control normal mammalian development. However, the components and mechanisms that define how Polycomb protein complexes achieve this remain enigmatic. Here, we use combinatorial genetic perturbation c...

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Vydáno v:Mol Cell
Hlavní autoři: Fursova, Nadezda A., Blackledge, Neil P., Nakayama, Manabu, Ito, Shinsuke, Koseki, Yoko, Farcas, Anca M., King, Hamish W., Koseki, Haruhiko, Klose, Robert J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6561741/
https://ncbi.nlm.nih.gov/pubmed/31029541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.03.024
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