Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-κB–driven inflammation and cardiovascular risk

Aging and psychosocial stress are associated with increased inflammation and disease risk, but the underlying molecular mechanisms are unclear. Because both aging and stress are also associated with lasting epigenetic changes, a plausible hypothesis is that stress along the lifespan could confer dis...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Zannas, Anthony S., Jia, Meiwen, Hafner, Kathrin, Baumert, Jens, Wiechmann, Tobias, Pape, Julius C., Arloth, Janine, Ködel, Maik, Martinelli, Silvia, Roitman, Maria, Röh, Simone, Haehle, Andreas, Emeny, Rebecca T., Iurato, Stella, Carrillo-Roa, Tania, Lahti, Jari, Räikkönen, Katri, Eriksson, Johan G., Drake, Amanda J., Waldenberger, Melanie, Wahl, Simone, Kunze, Sonja, Lucae, Susanne, Bradley, Bekh, Gieger, Christian, Hausch, Felix, Smith, Alicia K., Ressler, Kerry J., Müller-Myhsok, Bertram, Ladwig, Karl-Heinz, Rein, Theo, Gassen, Nils C., Binder, Elisabeth B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6561294/
https://ncbi.nlm.nih.gov/pubmed/31113877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1816847116
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