Chaperone-mediated reflux of secretory proteins to the cytosol during endoplasmic reticulum stress

Diverse perturbations to endoplasmic reticulum (ER) functions compromise the proper folding and structural maturation of secretory proteins. To study secretory pathway physiology during such “ER stress,” we employed an ER-targeted, redox-responsive, green fluorescent protein—eroGFP—that reports on a...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Igbaria, Aeid, Merksamer, Philip I., Trusina, Ala, Tilahun, Firehiwot, Johnson, Jeffrey R., Brandman, Onn, Krogan, Nevan J., Weissman, Jonathan S., Papa, Feroz R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2019
Soggetti:
PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6561268/
https://ncbi.nlm.nih.gov/pubmed/31101715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1904516116
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