Cardiac myosin activation with 2-deoxy-ATP via increased electrostatic interactions with actin

The naturally occurring nucleotide 2-deoxy-adenosine 5′-triphosphate (dATP) can be used by cardiac muscle as an alternative energy substrate for myosin chemomechanical activity. We and others have previously shown that dATP increases contractile force in normal hearts and models of depressed systoli...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Powers, Joseph D., Yuan, Chen-Ching, McCabe, Kimberly J., Murray, Jason D., Childers, Matthew Carter, Flint, Galina V., Moussavi-Harami, Farid, Mohran, Saffie, Castillo, Romi, Zuzek, Carla, Ma, Weikang, Daggett, Valerie, McCulloch, Andrew D., Irving, Thomas C., Regnier, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6561254/
https://ncbi.nlm.nih.gov/pubmed/31110001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1905028116
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