Protective role for the N-terminal domain of α-dystroglycan in Influenza A virus proliferation

α-Dystroglycan (α-DG) is a highly glycosylated basement membrane receptor that is cleaved by the proprotein convertase furin, which releases its N-terminal domain (α-DGN). Before cleavage, α-DGN interacts with the glycosyltransferase LARGE1 and initiates functional O-glycosylation of the mucin-like...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: de Greef, Jessica C., Slütter, Bram, Anderson, Mary E., Hamlyn, Rebecca, O’Campo Landa, Raul, McNutt, Ellison J., Hara, Yuji, Pewe, Lecia L., Venzke, David, Matsumura, Kiichiro, Saito, Fumiaki, Harty, John T., Campbell, Kevin P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2019
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6561248/
https://ncbi.nlm.nih.gov/pubmed/31097590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1904493116
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