EHMT2 and SETDB1 protect the maternal pronucleus from 5mC oxidation

Genome-wide DNA “demethylation” in the zygote involves global TET3-mediated oxidation of 5‐methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) in the paternal pronucleus. Asymmetrically enriched histone H3K9 methylation in the maternal pronuc...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Zeng, Tie-Bo, Han, Li, Pierce, Nicholas, Pfeifer, Gerd P., Szabó, Piroska E.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2019
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6561192/
https://ncbi.nlm.nih.gov/pubmed/31088968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1819946116
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